/* ============================================================
   Loki Clinical Dashboard — editorial design system
   Light palette default; dark via :root[data-theme="dark"]
   or OS fallback @media (prefers-color-scheme: dark).
   Sharp 0-radius, magenta accent, mono uppercase labels.
   ============================================================ */

:root {
  /* surfaces */
  --bg:        #F5F3F8;
  --bg-2:      #FFFFFF;
  --bg-3:      #EDE8F2;
  --surface:   #F0ECF5;

  /* ink */
  --ink:       #0B0E14;
  --ink-2:     #2F3647;
  --ink-3:     #525A6E;
  --muted:     #6A7286;
  --muted-2:   #8A90A0;

  /* borders */
  --border:    #D5DAE2;
  --border-2:  #C8CDD8;
  --border-3:  #8A90A0;

  /* elevation */
  --card-shadow: 0 1px 2px rgba(15,20,35,0.05), 0 1px 1px rgba(15,20,35,0.03);

  /* accent — magenta/fuchsia */
  --accent:        #CC00CC;
  --accent-2:      #AA00AA;
  --accent-bright: #EE00EE;
  --accent-surface:rgba(238,0,238,0.10);
  --accent-on:     #FFFFFF;

  /* semantic colors */
  --system-red:    #B5171F;
  --system-red-surface: #FDE1E1;
  --system-green:  #0E8F4B;
  --system-green-surface: #D4F4E1;
  --system-amber:  #B8801A;
  --system-amber-surface: #FFF0CC;

  /* clinical category palette (timeline, chips) */
  --cat-chemo:      #2A5CB8;
  --cat-immuno:     #5C3FB3;
  --cat-targeted:   #B5171F;
  --cat-radiation:  #CC7700;
  --cat-surgery:    #CC00CC;
  --cat-imaging:    #0E8F4B;
  --cat-pathology:  #525A6E;
  --cat-molecular:  #8A4F9F;
  --cat-biomarker:  #6A7286;
  --cat-other:      #8A90A0;

  /* focus ring */
  --focus-ring: 0 0 0 2px var(--bg-2), 0 0 0 4px var(--accent-2);

  /* motion */
  --ease-ui:   cubic-bezier(0.25, 0.1, 0.25, 1);
  --ease-out:  cubic-bezier(0.28, 0.11, 0.32, 1);
  --ease-spring: cubic-bezier(0.175, 0.885, 0.32, 1.275);
  --dur-xfast: 140ms;
  --dur-fast:  200ms;
  --dur-med:   400ms;

  /* type */
  --font-sans:    'DM Sans', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
  --font-mono:    'JetBrains Mono', ui-monospace, 'SF Mono', Menlo, Consolas, monospace;
  --font-display: 'Cormorant', Georgia, 'Times New Roman', serif;

  /* scale */
  --s-h1:     clamp(32px, 4vw, 48px);
  --s-h2:     28px;
  --s-h3:     20px;
  --s-body:   17px;
  --s-small:  15px;
  --s-ui:     14px;
  --s-mono:   14px;

  --lh-body:  1.62;
  --ls-tight: -0.02em;
  --ls-wide:  0.12em;
  --ls-badge: 0.20em;

  /* layout */
  --max-page:  1280px;
  --pad-x:     56px;
  --pad-x-mob: 20px;
  --hairline:  1px solid var(--border);

  /* radius — editorial = 0 (sharp) */
  --radius-s:  0;
  --radius-m:  0;
  --radius-l:  0;

  /* shadows */
  --shadow-s:  0 1px 3px rgba(15,20,35,0.05), 0 1px 2px rgba(15,20,35,0.03);
  --shadow-m:  0 4px 12px rgba(15,20,35,0.06), 0 1px 4px rgba(15,20,35,0.04);
  --shadow-l:  0 12px 40px rgba(15,20,35,0.1), 0 4px 12px rgba(15,20,35,0.04);
  --shadow-xl: 0 24px 80px rgba(15,20,35,0.14), 0 8px 24px rgba(15,20,35,0.06);
}

/* ---------- reset --------------------------------------- */
*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }
html {
  font-size: 16px;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  -webkit-text-size-adjust: 100%;
  background: var(--bg);
  scroll-behavior: smooth;
}
body {
  font-family: var(--font-sans);
  font-size: var(--s-body);
  line-height: var(--lh-body);
  color: var(--ink-2);
  background: var(--bg);
  min-height: 100vh;
  overflow-x: clip;
}
code, .mono {
  font-family: var(--font-mono);
  font-variant-numeric: tabular-nums;
}
a { color: inherit; text-decoration: none; }
::selection { background: var(--accent); color: var(--accent-on); }

/* ---------- a11y --------------------------------------- */
a:focus-visible,
button:focus-visible,
[tabindex]:focus-visible {
  outline: none;
  box-shadow: var(--focus-ring);
  border-radius: 2px;
}

/* ---------- page shell ---------------------------------- */
.loki-page {
  max-width: var(--max-page);
  margin: 0 auto;
  padding: 40px var(--pad-x) 80px;
}
@media (max-width: 768px) {
  .loki-page { padding: 28px var(--pad-x-mob) 56px; }
}

/* ---------- masthead ------------------------------------ */
.masthead { margin-bottom: 56px; }
.mast-top {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 16px;
  flex-wrap: wrap;
}
.wordmark {
  font-family: var(--font-display);
  font-size: clamp(26px, 2.4vw, 34px);
  font-weight: 600;
  letter-spacing: 0;
  color: var(--ink);
}
.badge {
  font-family: var(--font-mono);
  font-size: var(--s-ui);
  font-weight: 500;
  letter-spacing: var(--ls-badge);
  text-transform: uppercase;
  color: var(--accent);
  padding: 7px 14px;
  border: 1px solid var(--accent);
  border-radius: 999px;
  white-space: nowrap;
}
hr.rule {
  border: 0; height: 2px;
  background:
    linear-gradient(90deg,
      var(--accent-bright) 0,
      var(--accent-bright) 120px,
      var(--border) 120px,
      var(--border) 100%);
  margin: 22px 0;
}
.thesis {
  font-family: var(--font-display);
  font-size: clamp(26px, 3vw, 42px);
  line-height: 1.15;
  letter-spacing: var(--ls-tight);
  color: var(--ink);
  font-weight: 500;
  max-width: 860px;
  margin-top: 12px;
}
.thesis em {
  color: var(--accent);
  font-style: italic;
  font-weight: 500;
}
.byline {
  margin-top: 18px;
  font-family: var(--font-mono);
  font-size: var(--s-ui);
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
}
.byline a { color: var(--ink-2); border-bottom: 1px solid var(--border-2); }
.byline a:hover { color: var(--ink); border-color: var(--ink-3); }

.section-desc {
  max-width: 720px;
  font-size: var(--s-small);
  color: var(--ink-2);
  margin-bottom: 28px;
}

/* ---------- sections ------------------------------------ */
.section {
  margin-bottom: 72px;
}
.section-label {
  font-family: var(--font-mono);
  font-size: var(--s-ui);
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
  margin-bottom: 22px;
  padding-bottom: 14px;
  border-bottom: var(--hairline);
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  gap: 12px;
}
.section-label .label-meta {
  font-size: 12px;
  color: var(--muted);
  letter-spacing: var(--ls-wide);
}

/* ---------- patient picker (sticky chip row) ------------ */
.patient-picker {
  position: sticky;
  top: 0;
  z-index: 30;
  background: color-mix(in oklab, var(--bg) 92%, transparent);
  backdrop-filter: blur(14px) saturate(180%);
  -webkit-backdrop-filter: blur(14px) saturate(180%);
  border-bottom: var(--hairline);
  margin: 0 calc(var(--pad-x) * -1) 32px;
  padding: 14px var(--pad-x);
  display: flex;
  align-items: center;
  gap: 10px;
  flex-wrap: wrap;
}
@media (max-width: 768px) {
  .patient-picker {
    margin: 0 calc(var(--pad-x-mob) * -1) 24px;
    padding: 12px var(--pad-x-mob);
  }
}
.picker-label {
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
  margin-right: 4px;
}
.patient-chip {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  padding: 7px 14px;
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-2);
  background: var(--bg-2);
  border: 1px solid var(--border-2);
  cursor: pointer;
  user-select: none;
  transition: border-color var(--dur-xfast) var(--ease-ui),
              background var(--dur-xfast) var(--ease-ui),
              color var(--dur-xfast) var(--ease-ui);
}
.patient-chip:hover { border-color: var(--accent); color: var(--accent); }
.patient-chip.is-active {
  background: var(--accent);
  border-color: var(--accent);
  color: var(--accent-on);
}
.patient-chip .chip-meta {
  font-size: 10px;
  opacity: 0.7;
  letter-spacing: 0.04em;
}
.compare-toggle {
  margin-left: auto;
  display: inline-flex;
  align-items: center;
  gap: 8px;
  padding: 7px 14px;
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-2);
  background: var(--bg-2);
  border: 1px dashed var(--border-3);
  cursor: pointer;
}
.compare-toggle.is-active {
  border-style: solid;
  border-color: var(--accent);
  color: var(--accent);
  background: var(--accent-surface);
}

/* ---------- KPI cards ----------------------------------- */
.kpi-row {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 12px;
}
@media (max-width: 900px) { .kpi-row { grid-template-columns: repeat(2, 1fr); } }
@media (max-width: 500px) { .kpi-row { grid-template-columns: 1fr; } }
.kpi-card {
  border: var(--hairline);
  background: var(--bg-2);
  padding: 20px 20px 18px;
  display: flex;
  flex-direction: column;
  gap: 8px;
  min-height: 128px;
  transition: border-color var(--dur-fast) var(--ease-ui),
              box-shadow var(--dur-fast) var(--ease-out),
              transform var(--dur-fast) var(--ease-out);
  box-shadow: var(--card-shadow);
}
.kpi-card:hover {
  border-color: var(--accent);
  box-shadow: 0 6px 16px rgba(15,20,35,0.08), 0 1px 2px rgba(15,20,35,0.04);
  transform: translateY(-1px);
}
.kpi-card--accent {
  border-left: 3px solid var(--accent-bright);
  background: linear-gradient(180deg, var(--accent-surface), color-mix(in oklab, var(--accent-surface) 30%, var(--bg-2)));
}
.kpi-label {
  font-family: var(--font-mono);
  font-size: var(--s-ui);
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
}
.kpi-value {
  display: flex;
  align-items: baseline;
  gap: 8px;
  margin-top: 4px;
}
.kpi-big {
  font-family: var(--font-display);
  font-size: clamp(28px, 3vw, 40px);
  font-weight: 500;
  color: var(--ink);
  letter-spacing: var(--ls-tight);
  line-height: 1;
  font-variant-numeric: tabular-nums lining-nums;
}
.kpi-card--accent .kpi-big { color: var(--accent); }
.kpi-suffix {
  font-family: var(--font-mono);
  font-size: var(--s-ui);
  color: var(--ink-3);
  letter-spacing: 0.06em;
}
.kpi-sub {
  margin-top: auto;
  font-size: 12px;
  color: var(--muted);
  letter-spacing: 0.02em;
}

/* ---------- header / glance ----------------------------- */
.header-grid {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 360px;
  gap: 28px;
  align-items: start;
  margin-top: 20px;
}
@media (max-width: 960px) {
  .header-grid { grid-template-columns: 1fr; }
}
.glance {
  border: var(--hairline);
  background: var(--bg-2);
  padding: 22px 22px 20px;
  position: relative;
  box-shadow: var(--card-shadow);
}
.glance::before {
  content: "";
  position: absolute;
  top: 0; left: 0; width: 3px; height: 100%;
  background: var(--accent);
}
.glance-label {
  font-size: var(--s-ui);
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
  padding-bottom: 14px;
  margin-bottom: 16px;
  border-bottom: var(--hairline);
}
.glance-list { display: grid; gap: 10px; margin: 0; }
.glance-row {
  display: flex;
  justify-content: space-between;
  align-items: baseline;
  gap: 12px;
  font-family: var(--font-mono);
}
.glance-row dt {
  font-size: 13px;
  color: var(--ink-3);
  letter-spacing: 0.02em;
}
.glance-row dd {
  margin: 0;
  font-size: 13px;
  color: var(--ink-2);
  text-align: right;
}
.glance-row dd b {
  color: var(--accent);
  font-weight: 600;
  font-variant-numeric: tabular-nums;
}

/* ---------- status pills -------------------------------- */
.pill {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  padding: 3px 10px;
  font-family: var(--font-mono);
  font-size: 11px;
  font-weight: 600;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  border: 1px solid var(--border-2);
  background: var(--bg-3);
  color: var(--ink-2);
}
.pill-alive    { background: var(--system-green-surface); color: var(--system-green); border-color: color-mix(in oklab, var(--system-green) 40%, transparent); }
.pill-deceased { background: var(--system-red-surface); color: var(--system-red); border-color: color-mix(in oklab, var(--system-red) 40%, transparent); }
.pill-unknown  { background: var(--bg-3); color: var(--ink-3); border-color: var(--border-2); }
.pill-stage-iv { background: var(--system-red-surface); color: var(--system-red); border-color: color-mix(in oklab, var(--system-red) 40%, transparent); }
.pill-mutated  { background: var(--accent-surface); color: var(--accent); border-color: var(--accent); }

.recist-badge {
  display: inline-flex;
  padding: 3px 8px;
  font-family: var(--font-mono);
  font-size: 11px;
  font-weight: 600;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  border: 1px solid var(--border-2);
}
.recist-CR, .recist-iCR { background: var(--system-green-surface); color: var(--system-green); border-color: color-mix(in oklab, var(--system-green) 40%, transparent); }
.recist-PR, .recist-iPR { background: var(--accent-surface); color: var(--accent); border-color: var(--accent); }
.recist-SD, .recist-iSD { background: var(--bg-3); color: var(--ink-2); border-color: var(--border-2); }
.recist-PD, .recist-iPD { background: var(--system-red-surface); color: var(--system-red); border-color: color-mix(in oklab, var(--system-red) 40%, transparent); }

/* ---------- timeline (svg horizontal) ------------------- */
.timeline-wrap {
  border: var(--hairline);
  background: var(--bg-2);
  padding: 16px;
  overflow-x: auto;
  overflow-y: hidden;
  width: 100%;
  max-width: 100%;
  box-shadow: var(--card-shadow);
}
.timeline-svg {
  display: block;
  min-width: 100%;
  height: auto;
}
.timeline-band-label {
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  fill: var(--ink-3);
}
.timeline-axis-tick {
  font-family: var(--font-mono);
  font-size: 10px;
  fill: var(--muted);
}
.timeline-grid { stroke: var(--border); stroke-width: 1; opacity: 0.6; }
.timeline-band-divider { stroke: var(--border-2); stroke-width: 0.5; opacity: 0.5; }
.timeline-event-dot {
  cursor: pointer;
  transition: r var(--dur-xfast) var(--ease-ui), stroke-width var(--dur-xfast) var(--ease-ui);
}
.timeline-event-dot:hover { stroke: var(--ink); stroke-width: 2; }
.timeline-bar {
  cursor: pointer;
  transition: opacity var(--dur-xfast) var(--ease-ui);
}
.timeline-bar:hover { opacity: 0.78; }

.timeline-legend {
  display: flex;
  flex-wrap: wrap;
  gap: 12px;
  margin-top: 14px;
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
}
.timeline-legend .legend-item { display: inline-flex; align-items: center; gap: 6px; }
.timeline-legend .legend-swatch {
  width: 12px; height: 12px;
  display: inline-block;
  border: 1px solid var(--border-2);
}

.tt-tooltip {
  position: fixed;
  pointer-events: none;
  padding: 8px 12px;
  background: var(--ink);
  color: var(--bg-2);
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: 0.04em;
  line-height: 1.5;
  max-width: min(360px, calc(100vw - 24px));
  white-space: normal;
  overflow-wrap: anywhere;
  word-break: break-word;
  box-shadow: var(--shadow-l);
  z-index: 80;
  opacity: 0;
  transition: opacity var(--dur-xfast) var(--ease-ui);
}
.tt-tooltip .tt-body {
  white-space: pre-wrap;
}
.tt-tooltip.is-visible { opacity: 1; }
.tt-tooltip .tt-title { color: var(--accent-bright); font-weight: 600; }

/* ---------- chart cards --------------------------------- */
.chart-grid {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 16px;
}
@media (max-width: 800px) { .chart-grid { grid-template-columns: 1fr; } }
.chart-wrap {
  border: var(--hairline);
  background: var(--bg-2);
  padding: 18px;
  min-height: 280px;
  display: flex;
  flex-direction: column;
  gap: 10px;
  box-shadow: var(--card-shadow);
}
.chart-title {
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  gap: 8px;
}
.chart-title .chart-meta {
  font-size: 10px;
  color: var(--muted);
}
.chart-canvas-wrap {
  position: relative;
  flex: 1;
  min-height: 220px;
}
.chart-canvas-wrap canvas { display: block; width: 100% !important; height: 100% !important; }

/* ---------- treatment table ----------------------------- */
.clinical-table-wrap {
  border: var(--hairline);
  background: var(--bg-2);
  box-shadow: var(--card-shadow);
  overflow: hidden;
}
.clinical-table {
  width: 100%;
  border-collapse: collapse;
  font-family: var(--font-mono);
  font-size: var(--s-mono);
}
.clinical-table thead { border-bottom: 1px solid var(--border-2); background: var(--bg-3); }
.clinical-table th {
  padding: 12px 16px;
  font-size: var(--s-ui);
  font-weight: 500;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
  text-align: left;
  white-space: nowrap;
}
.clinical-table td {
  padding: 12px 16px;
  font-size: var(--s-small);
  color: var(--ink-2);
  border-bottom: 1px solid var(--border);
  vertical-align: top;
}
.clinical-table tr:last-child td { border-bottom: 0; }
.cat-tag {
  display: inline-block;
  padding: 2px 8px;
  font-family: var(--font-mono);
  font-size: 11px;
  font-weight: 600;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  border: 1px solid currentColor;
  color: var(--cat-other);
}
.cat-tag.cat-chemo     { color: var(--cat-chemo); }
.cat-tag.cat-immuno    { color: var(--cat-immuno); }
.cat-tag.cat-targeted  { color: var(--cat-targeted); }
.cat-tag.cat-radiation { color: var(--cat-radiation); }
.cat-tag.cat-surgery   { color: var(--cat-surgery); }
.cat-tag.cat-imaging   { color: var(--cat-imaging); }
.cat-tag.cat-pathology { color: var(--cat-pathology); }
.cat-tag.cat-molecular { color: var(--cat-molecular); }
.cat-tag.cat-biomarker { color: var(--cat-biomarker); }

/* ---------- imaging gallery ----------------------------- */
.imaging-list {
  display: grid;
  gap: 12px;
}
.imaging-row {
  display: grid;
  grid-template-columns: 100px 140px minmax(0, 1fr) auto;
  gap: 16px;
  align-items: center;
  padding: 14px 18px;
  border: var(--hairline);
  background: var(--bg-2);
  box-shadow: var(--card-shadow);
}
@media (max-width: 720px) {
  .imaging-row { grid-template-columns: 100px 1fr; }
  .imaging-row .imaging-impression { grid-column: 1 / -1; }
  .imaging-row .imaging-action { grid-column: 1 / -1; justify-self: start; }
}
.imaging-date {
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: 0.04em;
  color: var(--ink-3);
}
.modality-badge {
  display: inline-flex;
  align-items: center;
  padding: 3px 10px;
  font-family: var(--font-mono);
  font-size: 11px;
  font-weight: 600;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  background: var(--bg-3);
  color: var(--cat-imaging);
  border: 1px solid color-mix(in oklab, var(--cat-imaging) 40%, transparent);
}
.imaging-impression {
  font-size: 13px;
  color: var(--ink-2);
  line-height: 1.5;
}
.btn-open {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  padding: 6px 12px;
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--accent);
  background: var(--bg-2);
  border: 1px solid var(--accent);
  cursor: pointer;
  transition: background var(--dur-xfast) var(--ease-ui), color var(--dur-xfast) var(--ease-ui);
}
.btn-open:hover { background: var(--accent); color: var(--accent-on); }

/* ---------- pathology + molecular grid ------------------ */
.pathmol-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 18px;
}
.pathmol-card {
  border: var(--hairline);
  background: var(--bg-2);
  padding: 18px;
  box-shadow: var(--card-shadow);
  min-width: 0;
  overflow: hidden;
}
.pathmol-card .clinical-table-wrap,
.pathmol-card .mol-group {
  overflow-x: auto;
  max-width: 100%;
}
.pathmol-card .clinical-table {
  table-layout: auto;
  word-break: break-word;
}
.pathmol-card .clinical-table td {
  white-space: normal;
  overflow-wrap: anywhere;
}
.pathmol-card h3 {
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
  margin-bottom: 12px;
  padding-bottom: 10px;
  border-bottom: var(--hairline);
}
.mol-group { margin-bottom: 18px; }
.mol-group-title {
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--accent);
  margin-bottom: 8px;
}

/* ---------- WSI viewer ---------------------------------- */
.wsi-tabs {
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
  margin-bottom: 12px;
}
.wsi-tab {
  padding: 7px 14px;
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-2);
  background: var(--bg-2);
  border: 1px solid var(--border-2);
  cursor: pointer;
  transition: border-color var(--dur-xfast) var(--ease-ui), color var(--dur-xfast) var(--ease-ui);
}
.wsi-tab:hover { border-color: var(--accent); color: var(--accent); }
.wsi-tab.is-active {
  background: var(--accent);
  border-color: var(--accent);
  color: var(--accent-on);
}
.wsi-viewer-wrap {
  position: relative;
  width: 100%;
  min-height: 480px;
  aspect-ratio: 16 / 10;
  background: var(--bg-3);
  border: var(--hairline);
  box-shadow: var(--card-shadow);
  overflow: hidden;
}
.wsi-viewer-wrap.is-empty {
  display: flex;
  align-items: center;
  justify-content: center;
  padding: 32px;
  text-align: center;
}
.wsi-empty-text {
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
  line-height: 1.6;
}
.wsi-empty-text code {
  display: inline-block;
  padding: 2px 6px;
  background: var(--bg-2);
  border: 1px solid var(--accent);
  color: var(--accent);
  margin-top: 6px;
}
#wsi-viewer { position: absolute; inset: 0; width: 100%; height: 100%; }

.wsi-loader {
  position: absolute;
  inset: 0;
  display: flex;
  flex-direction: column;
  align-items: center;
  justify-content: center;
  gap: 14px;
  background: var(--bg-3);
  z-index: 5;
  pointer-events: none;
}
.wsi-loader[hidden] { display: none; }
.wsi-loader__spinner {
  width: 44px;
  height: 44px;
  border: 3px solid var(--bg-2);
  border-top-color: var(--accent);
  border-radius: 50%;
  animation: wsi-spin 0.9s linear infinite;
}
.wsi-loader__label {
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
}
@keyframes wsi-spin { to { transform: rotate(360deg); } }

/* ---------- documents library --------------------------- */
.doc-library { display: grid; gap: 10px; }
.doc-cat {
  border: var(--hairline);
  background: var(--bg-2);
  box-shadow: var(--card-shadow);
}
.doc-cat-header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 12px 18px;
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-2);
  cursor: pointer;
  user-select: none;
  background: var(--bg-3);
}
.doc-cat-header:hover { color: var(--accent); }
.doc-cat-count {
  color: var(--muted);
  font-size: 11px;
}
.doc-cat-items {
  display: none;
  padding: 8px 18px 12px;
}
.doc-cat.is-open .doc-cat-items { display: block; }
.doc-cat-item {
  display: flex;
  align-items: center;
  gap: 10px;
  padding: 8px 0;
  border-bottom: 1px solid var(--border);
  font-size: 13px;
  color: var(--ink-2);
}
.doc-cat-item:last-child { border-bottom: 0; }
.doc-cat-item .doc-icon {
  color: var(--accent);
  width: 16px;
  height: 16px;
  flex-shrink: 0;
}
.doc-cat-item .doc-title { flex: 1; }
.doc-cat-item .doc-link {
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--accent);
  border-bottom: 1px solid currentColor;
}
.doc-cat-item .doc-link:hover { color: var(--accent-2); }

/* ---------- compare 3-up -------------------------------- */
.compare-grid {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 16px;
}
@media (max-width: 1100px) { .compare-grid { grid-template-columns: 1fr; } }
.compare-card {
  border: var(--hairline);
  background: var(--bg-2);
  padding: 18px;
  box-shadow: var(--card-shadow);
}
.compare-card h3 {
  font-family: var(--font-display);
  font-size: 22px;
  font-weight: 500;
  color: var(--ink);
  margin-bottom: 4px;
}
.compare-card .compare-sub {
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
  margin-bottom: 14px;
}
.compare-card .compare-kpi {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 8px;
  margin-bottom: 14px;
}
.compare-card .compare-kpi .kpi-mini {
  border: 1px solid var(--border);
  padding: 8px 10px;
}
.compare-card .compare-kpi .kpi-mini .lbl {
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
  display: block;
  margin-bottom: 2px;
}
.compare-card .compare-kpi .kpi-mini .val {
  font-family: var(--font-display);
  font-size: 20px;
  color: var(--ink);
  line-height: 1.1;
  font-variant-numeric: tabular-nums;
}

/* ---------- empty state --------------------------------- */
.empty-state {
  max-width: 560px;
  margin: 60px auto;
  padding: 36px 28px;
  border: 2px dashed var(--accent);
  text-align: center;
  background: var(--accent-surface);
}
.empty-state h2 {
  font-family: var(--font-display);
  font-size: 28px;
  font-weight: 500;
  color: var(--ink);
  margin-bottom: 10px;
}
.empty-state p {
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-2);
  line-height: 1.7;
  margin-bottom: 14px;
}
.empty-state code {
  display: block;
  padding: 10px 14px;
  margin: 8px auto;
  max-width: 480px;
  background: var(--bg-2);
  border: 1px solid var(--accent);
  color: var(--accent);
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: 0.02em;
  text-transform: none;
}

/* ---------- doc / image modals (re-used) ---------------- */
.doc-modal,
.lightbox {
  position: fixed;
  inset: 0;
  z-index: 9999;
  display: flex;
  align-items: center;
  justify-content: center;
  opacity: 0;
  visibility: hidden;
  transition: opacity var(--dur-med) var(--ease-out), visibility var(--dur-med);
}
.doc-modal.active,
.lightbox.active { opacity: 1; visibility: visible; }
.doc-backdrop,
.lightbox-backdrop {
  position: absolute;
  inset: 0;
  background: rgba(15, 20, 35, 0.78);
  backdrop-filter: blur(20px) saturate(180%);
  -webkit-backdrop-filter: blur(20px) saturate(180%);
}
.doc-modal-content {
  position: relative;
  width: min(960px, 92vw);
  height: min(86vh, 1100px);
  display: flex;
  flex-direction: column;
  background: var(--bg-2);
  border: 1px solid var(--border);
  box-shadow: var(--shadow-xl);
  animation: lbIn 0.4s var(--ease-spring);
  overflow: hidden;
}
.doc-modal-bar {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 16px;
  padding: 12px 18px;
  background: var(--bg-3);
  border-bottom: 1px solid var(--border);
}
.doc-modal-caption {
  font-family: var(--font-mono);
  font-size: 12px;
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-2);
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}
.doc-modal-content iframe {
  flex: 1 1 auto;
  width: 100%;
  border: 0;
  background: var(--bg-2);
}
.doc-close,
.lightbox-close {
  position: fixed;
  top: 24px;
  right: 24px;
  z-index: 10002;
  background: rgba(255,255,255,0.08);
  border: 1px solid rgba(255,255,255,0.25);
  color: rgba(255,255,255,0.9);
  width: 44px;
  height: 44px;
  border-radius: 999px;
  display: flex;
  align-items: center;
  justify-content: center;
  cursor: pointer;
  transition: background var(--dur-xfast) var(--ease-ui),
              border-color var(--dur-xfast) var(--ease-ui),
              transform var(--dur-xfast) var(--ease-ui);
  backdrop-filter: blur(12px);
  -webkit-backdrop-filter: blur(12px);
}
.doc-close:hover,
.lightbox-close:hover { background: rgba(255,255,255,0.2); transform: scale(1.08); }
.lightbox-content {
  position: relative;
  display: flex;
  flex-direction: column;
  align-items: center;
  justify-content: center;
  gap: 20px;
  animation: lbIn 0.4s var(--ease-spring);
}
@keyframes lbIn {
  from { transform: scale(0.92); opacity: 0; }
  to   { transform: scale(1); opacity: 1; }
}
.lightbox-content img {
  display: block;
  max-width: 92vw;
  max-height: 82vh;
  width: auto;
  height: auto;
  object-fit: contain;
  box-shadow: var(--shadow-xl);
  background: var(--bg-2);
  border: 1px solid var(--border);
}
.lightbox-caption {
  color: rgba(255,255,255,0.5);
  font-family: var(--font-mono);
  font-size: var(--s-ui);
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
}

/* ---------- footer -------------------------------------- */
.foot {
  margin-top: 88px;
  padding-top: 26px;
  border-top: var(--hairline);
  text-align: center;
}
.foot-inner {
  display: flex;
  justify-content: center;
  flex-wrap: wrap;
  gap: 10px;
  font-family: var(--font-mono);
  font-size: var(--s-ui);
  letter-spacing: var(--ls-wide);
  text-transform: uppercase;
  color: var(--ink-3);
}
.foot-inner a {
  color: var(--ink-2);
  border-bottom: 1px solid var(--border-2);
  transition: color var(--dur-xfast) var(--ease-ui), border-color var(--dur-xfast) var(--ease-ui);
}
.foot-inner a:hover { color: var(--ink); border-color: var(--accent); }

/* ---------- theme toggle -------------------------------- */
.mast-right {
  display: inline-flex;
  align-items: center;
  gap: 12px;
  flex-wrap: wrap;
  justify-content: flex-end;
}
.theme-toggle {
  position: relative;
  flex-shrink: 0;
  width: 40px;
  height: 40px;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  border: 1px solid var(--border-2);
  border-radius: 999px;
  background: var(--bg-2);
  color: var(--ink-2);
  cursor: pointer;
  transition: border-color var(--dur-fast) var(--ease-ui),
              background var(--dur-fast) var(--ease-ui),
              transform var(--dur-fast) var(--ease-ui);
  box-shadow: 0 2px 8px rgba(15,20,35,0.06);
}
.theme-toggle:hover { border-color: var(--border-3); background: var(--bg-3); }
.theme-toggle:active { transform: scale(0.95); }
.theme-toggle svg { width: 18px; height: 18px; display: block; }
.theme-toggle .icon-sun  { display: none; }
.theme-toggle .icon-moon { display: block; }
:root[data-theme="dark"] .theme-toggle .icon-sun  { display: block; }
:root[data-theme="dark"] .theme-toggle .icon-moon { display: none; }
@media (prefers-color-scheme: dark) {
  :root:not([data-theme]) .theme-toggle .icon-sun  { display: block; }
  :root:not([data-theme]) .theme-toggle .icon-moon { display: none; }
}

/* ---------- reduced motion ------------------------------ */
@media (prefers-reduced-motion: reduce) {
  *, *::before, *::after {
    animation-duration: 0.001ms !important;
    animation-iteration-count: 1 !important;
    transition-duration: 0.001ms !important;
    scroll-behavior: auto !important;
  }
}

/* ============================================================
   DARK MODE
   ============================================================ */
:root[data-theme="dark"],
:root[data-theme="dark"] body { color-scheme: dark; }

:root[data-theme="dark"] {
  --bg:        #0B0E14;
  --bg-2:      #151A28;
  --bg-3:      #1E2436;
  --surface:   #192030;
  --card-shadow: none;

  --ink:       #F3F5F9;
  --ink-2:     #C5CBE9;
  --ink-3:     #8B93B0;
  --muted:     #7A82A0;
  --muted-2:   #828898;

  --border:    #2A3148;
  --border-2:  #3A4568;
  --border-3:  #4A5578;

  --accent:          #EE00EE;
  --accent-2:        #FF44FF;
  --accent-bright:   #EE00EE;
  --accent-surface:  rgba(238,0,238,0.12);
  --accent-on:       #FFFFFF;

  --system-red:    #FF8F8F;
  --system-red-surface: rgba(255,143,143,0.12);
  --system-green:  #5EE695;
  --system-green-surface: rgba(94,230,149,0.14);
  --system-amber:  #FFD86B;
  --system-amber-surface: rgba(255,216,107,0.12);

  --cat-chemo:      #89B5FF;
  --cat-immuno:     #CDB0FF;
  --cat-targeted:   #FF8F8F;
  --cat-radiation:  #FFB562;
  --cat-surgery:    #FF44FF;
  --cat-imaging:    #5EE695;
  --cat-pathology:  #C5CBE9;
  --cat-molecular:  #D89FFF;
  --cat-biomarker:  #8B93B0;
  --cat-other:      #7A82A0;

  --focus-ring: 0 0 0 2px var(--bg), 0 0 0 4px var(--accent);
}

:root[data-theme="dark"] body {
  background:
    radial-gradient(ellipse 900px 520px at 20% -10%, rgba(137,181,255,0.05), transparent 60%),
    radial-gradient(ellipse 700px 420px at 120% 0%, rgba(205,176,255,0.04), transparent 60%),
    var(--bg);
}

:root[data-theme="dark"] .patient-picker {
  background: color-mix(in oklab, var(--bg) 88%, transparent);
}
:root[data-theme="dark"] .doc-backdrop,
:root[data-theme="dark"] .lightbox-backdrop {
  background: rgba(0, 0, 0, 0.85);
}

/* OS fallback */
@media (prefers-color-scheme: dark) {
  :root:not([data-theme]) {
    --bg: #0B0E14;  --bg-2: #151A28;  --bg-3: #1E2436;  --surface: #192030;
    --card-shadow: none;
    --ink: #F3F5F9;  --ink-2: #C5CBE9;  --ink-3: #8B93B0;
    --muted: #7A82A0;  --muted-2: #828898;
    --border: #2A3148;  --border-2: #3A4568;  --border-3: #4A5578;
    --accent: #EE00EE;  --accent-2: #FF44FF;  --accent-bright: #EE00EE;
    --accent-surface: rgba(238,0,238,0.12);  --accent-on: #FFFFFF;
    --system-red: #FF8F8F;  --system-red-surface: rgba(255,143,143,0.12);
    --system-green: #5EE695;  --system-green-surface: rgba(94,230,149,0.14);
    --system-amber: #FFD86B; --system-amber-surface: rgba(255,216,107,0.12);
    --cat-chemo: #89B5FF;  --cat-immuno: #CDB0FF;  --cat-targeted: #FF8F8F;
    --cat-radiation: #FFB562;  --cat-surgery: #FF44FF;  --cat-imaging: #5EE695;
    --cat-pathology: #C5CBE9;  --cat-molecular: #D89FFF;  --cat-biomarker: #8B93B0;
    --focus-ring: 0 0 0 2px var(--bg), 0 0 0 4px var(--accent);
    color-scheme: dark;
  }
  :root:not([data-theme]) body {
    background:
      radial-gradient(ellipse 900px 520px at 20% -10%, rgba(137,181,255,0.05), transparent 60%),
      radial-gradient(ellipse 700px 420px at 120% 0%, rgba(205,176,255,0.04), transparent 60%),
      var(--bg);
  }
  :root:not([data-theme]) .patient-picker {
    background: color-mix(in oklab, var(--bg) 88%, transparent);
  }
  :root:not([data-theme]) .doc-backdrop,
  :root:not([data-theme]) .lightbox-backdrop {
    background: rgba(0, 0, 0, 0.85);
  }
}